In GSE17538 colon cancer patient cohort with available clinical information (n = 232), we found that patients whose tumour expressed a high‐level expression of OPN had a mean survival time of 78.6 months (95% CI = 66.2‐91.0 months), which was significantly shorter compared to those patients whose tumour expressed a low level of OPN, who had a mean survival time of 113.5 months (95% CI = 102.6‐124.5 months, P < .001; Figure 5B). Here, SPP1 is linked to malignant colon neoplasm.