THBD and chronic kidney disease: Moreover, GPA patients with chronic kidney disease were characterized by higher thrombomodulin level (11.7 [9.4–17.6) vs. 5.4 [4.4–6.9] ng/ml, p < 0.001) and VCAM-1 level (1258.2 [893.2–1457.7] vs. 747.4 [546.9–917.5] ng/ml, p < 0.001).