In the Steno-2 study, we compared conventional multifactorial management of patients with type 2 diabetes and microalbuminuria (24 h urinary albumin excretion 30–300 mg) with intensified multifactorial intervention targeting known modifiable risk factors with individualised lifestyle intervention and tailored polypharmacy [13–15] at a specialised diabetes clinic. This evidence concerns the gene ALB and type 2 diabetes mellitus.