TLR4 and subarachnoid hemorrhage: The other research has demonstrated that resveratrol treatment in rat with subarachnoid hemorrhage (SAH) could obviously decrease the expression of Toll-like receptor 4 (TLR4), high-mobility group box1 protein, myeloid differentiation factor (MyD88), and NF-κB. In addition, resveratrol remarkably inhibited microglial activation and proinflammatory mediators, which gave rise to the alleviation of neuronal apoptosis, cerebral edema, and behavior deficits at 24 h after SAH [22].