IL18 and atherosclerosis: For example, in an Apoe−/− mouse model fed with a high-fat diet, arglabin was demonstrated to effectively reduce the secretion of IL-1β and IL-18, convert proinflammatory M1 macrophage into anti-inflammatory M2 macrophage, induce autophagy, decrease the cholesterol level in plasma, and thus reduce the atherosclerosis size [51].