F5 and Venous thrombosis: Defects in blood coagulation and fibrinolysis have been described in patients with BD with or without thrombosis, and accordingly, we found downregulation of genes encoding for proteins that have an anticoagulant effect (i.e., TFPI, PROS1, and PROCR/EPCR) and upregulation of transcripts which promote the coagulation process (including THBS1, F5, and LMAN1).