Glucocorticoids have been shown to inhibit DC activation [70] and promote a tolerogenic phenotype [71] although the stimulation through TLR-7 and TLR-9 can confer resistance to glucocorticoids in dendritic cells by promoting NFκB activation in both human cells and murine models of SLE [18]. This evidence concerns the gene NFKB1 and systemic lupus erythematosus.