A previous study of pediatric SLE patients reported an IFN signature in both female and males [6] while a recent study of treatment-naïve girls and boys with childhood onset SLE further described a “TNF signature” present in boys but absent in girls [78], suggesting that sex may affect disease differently by promoting type I IFN-dependent and type I IFNs-independent pathways. The gene discussed is TNF; the disease is systemic lupus erythematosus.