Despite the specific mechanisms underlying the increased uVDBP excretion in patients with DN were not fully uncovered, several evidences support that the enhanced excretion of megalin/cubilin (i.e., multiligand endocytic receptors expressed in the brush border of proximal renal tubular cells and participate in the reuptake of filtered low-molecular weight proteins like albumin and VDBP from the glomerular filtrate) in the urine of patients with DN could play a role [47, 48]. This evidence concerns the gene GC and liver dysplastic nodule.