Saurel et al. have shown marked expression of angiogenic factors, including VEGFA, VEGFC, FIGF, and SPP1 by qRT-PCR in a case of cutaneous IVLBCL compared to other types of DLBCLs which may explain the apparent tropism of IVLBCL to vascular neoplasms including benign hemangiomas [15]. This evidence concerns the gene SPP1 and vascular neoplasm.