CLN5 and chronic kidney disease: A variety of risk factors, such as hyperphosphatemia, secondary hyperparathyroidism, chronic inflammation, and oxidative stress, may induce the formation of vascular calcification in CKD patients [12, 13] and are accompanied by the increased expression of bone matrix proteins, including bone morphogenetic proteins (BMPs), osteopontin, osteoprotegerin, and osteocalcin.