Tumor microenvironment (TME) was characterized by hypoxia, acidosis, and dense extracellular matrix, providing tumors with resistance to various therapies, which could be effectively changed by the intravenous injection of human serum albumin (HAS)-chlorine e6 (Ce6)-CAT-paclitaxel (PTX) nanoparticles, enzyme-loaded therapeutic albumin nanoparticles. Here, CAT is linked to neoplasm.