Moreover, NLRP3 gene polymorphisms have been explored as possible predisposing factors for development of a variety of diseases associated with autoimmune and/or inflammatory responses, such as RA, Crohn's disease, SLE, celiac disease, AIDS, Alzheimer's disease, abdominal aortic aneurysms [17], atopic dermatitis [17, 18], and malignant melanoma [19]. NLRP1 and NLRP3 polymorphisms have been associated with psoriasis in the European population [9, 12]; however, their association with psoriasis in other populations remains unexplored. This evidence concerns the gene NLRP3 and early-onset autosomal dominant Alzheimer disease.