HMGB1 and lung cancer: According to the staining intensity, we chose different time nodes using the survival analyses, which showed that the postoperative total survival percentage of high HMGB1 expression was significantly lower than low HMGB1 expression for lung cancer patients (P = 0.0011, HR = 0.0011, 95% CI: 0.2623 0.7166; Figure 1).