Although we did not check the association between LATS1 methylation and YAP1 protein content in our previous study, other authors in the study of ccRCC 786-O cell line observed that the demethylation of LATS1 promoter was strongly associated with upregulation of YAP1 protein in cells [29]. Here, LATS1 is linked to nonpapillary renal cell carcinoma.