Yes-associated protein 1 (YAP1) may be considered as one of the oncoproteins that play an important role in ccRCC pathogenesis, since deregulation of this gene (either at mRNA or protein level) was associated with progression of other malignancies [3–5]. YAP1 gene is located at 11q22 chromosome and this locus is amplified in many tumors [6]. YAP1, as an oncogene, plays a role in cells' proliferation and furthermore it is also involved in other mechanisms of cancer progression such as epithelial-mesenchymal transition, cell migration, and formation of metastasis [7]. Here, YAP1 is linked to nonpapillary renal cell carcinoma.