LATS1 and nonpapillary renal cell carcinoma: Also the TCGA data obtained for 469 ccRCC tumors shows altered YAP1 mRNA and LATS1 mRNA level in cancer tumors. YAP1 mRNA was upregulated in 9.6% and downregulated in 4.9% cases and LATS1 mRNA was upregulated in 4.5% and downregulated in 10.7% cases, when a-z score threshold was set for 1.5-fold change [30].