PVT1 and cervical carcinoma: For example, Zhang et al. explained the regulatory mechanism of lnc-RNA PVT1, which is overexpressed in cervical cancer: PVT1 binds with EZH2 directly to activate EZH2 to increase the histone H3K27 trimethylation level of the miR-200b promoter so that downexpressed miR-200b enhanced proliferation, cycle progression, and migration [93].