Hypermethylation of DOC2B promotes colony formation and cell proliferation, induces cell cycle arrest, and represses cell migration and invasion deeply; the promoter region of the DOC2B gene inhibiting AKT1 and ERK1/2 signaling is hypermethylated in premalignant and malignant cervical tissues and cervical cancer cell lines [40]. Here, DOC2B is linked to cervical carcinoma.