DAPK1 and neoplasm: It has been shown that cisplatin as well as 5-azacytidine touch off cytotoxic and growth inhibitory effects in vitro by demethylating the promoters of ESR1, BRCA1, RASSF1A, MLH1, MYOD1, hTERT, and DAPK1 to reexpress these tumor-associated genes [94].