The fourth subject was a lean PCOS, who was hyper stimulated with a dosage of 1,250 IU of FSH, with 11 dominant follicles ≥17 mm and 7 intermediate follicles of 14–16 mm on the day of trigger and peak E2=7665 pg/ml, was triggered with GnRHa and an OPU 35 hr later which resulted in EFS. The gene discussed is BRD2; the disease is polycystic ovary syndrome.