CDH1 and neoplasm: This result could indicate that tumor invasion is related to alterations in cell-cell and cell-ECM interactions, mediated by cell adhesion molecules [34]; it is possible that the gradual loss of the expression of Ecad and Syn1E as well as the gradual increase in Syn1S expression are related to the promotion of tumor cell invasion to the stroma, and with the capacity to gain migratory capability and autonomous cell survival.