The role of stromal CAV1 in the lung cancer is controversial: in two studies with small case numbers (n = 37 and n = 62), the stromal CAV1 expression was correlated with improved survival [32, 33], whereas in a large study (n = 412), the expression of stromal CAV1 in lung adenocarcinoma (AC) was associated with a significantly worse overall survival [34]. Here, CAV1 is linked to lung adenocarcinoma.