CAV2 and neoplasm: Two negative tumor samples exhibit a staining of the stroma surrounding the lymph node metastasis, whereas 15 (38.4%) samples with a positive staining for CAV2 in the tumor stroma showed no staining in the stroma of lymph node metastasis (p = 0.001), indicating a downregulation of stromal CAV2 in the metastatic lymph nodes.