SLC2A9 and metabolic disease: These transporters are arranged in a pocket-like or a scaffolding-type structure around the renal tubules, and the genes coding for them acts in combination to transport the urate and other molecules. Mutation or polymorphism or loss of genes coding for transport causes hyperuricemia, which increases the glycation of proteins, and later could be responsible for the development of metabolic disorders like T2DM. Hence, identification of mutations in the genes encoding urate transporters will play a crucial role in the control and prevention of metabolic disorders.