One rare and potentially dangerous side effect is angioedema.<h4>Case report</h4>We present the case of a patient treated for ischemic stroke who developed angioedema and discuss the etiology and risk factors for this rare, but dangerous side effect.<h4>Conclusion</h4>Given the frequent and widespread use of tPA, awareness of the rare life-threatening side effects is paramount. The gene discussed is PLAT; the disease is ischemic stroke.