Accumulating evidence of the LUZP2 role in the genetic component of a spectrum of neurocognitive phenotypes, based on genome-wide association with AD, schizophrenia, cognitive, and memory functions [11–17], as well as on the findings of exonic variants shared among the affected siblings with a familial variant of Alzheimer's disease with neuroimaging features of Alzheimer's disease but lacking amyloid-b deposits in the brain [47], suggests its functional implication in the neurodegeneration and impaired cognition in humans. The gene discussed is LUZP2; the disease is early-onset autosomal dominant Alzheimer disease.