AIRE and systemic lupus erythematosus: Among genetic factors, variant of AIRE (Autoimmune Regulator) gene has been correlated with autoimmune manifestations in the APECED8,9, rheumatoid arthritis10,11, the immune deficiency omenn syndrome12, alopecia aerate13, and lupus like panniculitis in patients with APECED14 but not with type I diabetes, addison disease15 and Graves’ disease16, myasthenia gravis17 as well as inflammatory bowel disease18.