A series of them can be listed, from carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA 19-9), microsatellite instability (MSI), V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), tumor protein p53 to circulating DNA, RNA and circulating tumor cells (CTCs) [7]. The gene discussed is KRAS; the disease is neoplasm.