IGFBP3 and esophageal cancer: Loss of IGFBP3 also mediates acquired resistance to EGFR tyrosine kinase inhibitors [37], and upregulation of IGFBP3 is reportedly associated with increased chemosensitivity of esophageal cancer cells to nimotuzumab (anti-EGFR monoclonal antibody) with CDDP [38].