Yan et al. demonstrated that knockdown of CNPY2 reversibly increased p53 activity using the colorectal cancer cell line HCT116 and suggested that CNPY2 plays a critical role in CRC development by enhancing cell growth, migration, and angiogenesis and by inhibiting apoptosis through negative regulation of the p53 pathway [23]. The gene discussed is CNPY2; the disease is colorectal carcinoma.