As shown in Table 4, significant factors by univariate analysis included Ki-67 ≥ 8.2% (p = 0.009), tumor size ≥ 42 mm (p = 0.007), vascular invasion (p = 0.009), lymphatic invasion (p = 0.012) and CNPY2 positive (p = 0.010). The gene discussed is CNPY2; the disease is neoplasm.