Nucleotide-binding oligomerization domain-like receptors (NLRs) play a vital role in innate immunity involved in some chronic kidney diseases such as diabetic nephropathy [26, 27]; NLRP3 with a pyrin domain 3, as one important component of NLRs, is a key protein of inflammasome complex consisting of NLRP3, ASC, and pro-caspase-1. Here, NLRP3 is linked to diabetic kidney disease.