SOD2 and obesity due to melanocortin 4 receptor deficiency: In mouse studies, manganese [III] tetrakis [5,10,15,20]-benzoic acid porphyrin (MnTBAP), a nonpeptidic mimic of MnSOD, significantly reduced excess body weight and serum superoxide anion generation [79], ameliorated preexisting obesity, and improved insulin action by reducing caloric intake [80].