BRCA1 and early-onset autosomal dominant Alzheimer disease: One of the most latest studies demonstrated a hypomethylated region of the BRCA1 promoter in AD postmortem brains accompanied by an upregulation and cytoplasmic mislocalisation of the BRCA1 [17], which fully agrees with our recent results pointing to BRCA1 as the central player in DNA damage response- (DDR-) related pathology in Alzheimer's disease [18].