CFTR and chronic obstructive pulmonary disease: In addition to roflumilast and ivacaftor, the next generation of potentiators targeting the CFTR gating defect in smoke-exposed human tissues and CFTR correctors (VX809, lumacaftor, and ABBV/GLPG-2222) restoring and/or enhancing CFTR trafficking to cell surface may provide novel strategies in COPD treatments [87].