Apart from the association of the loss of CFTR activity and manifestations in COPD lungs, a correlation between the dysfunction of systemic CFTR and abnormal gland secretion in skins has also been defined in COPD patients; that is, the β-adrenergic sweat rate was significantly reduced in COPD patients, which was associated with the severity and clinical symptoms of COPD [39, 48]. Here, CFTR is linked to chronic obstructive pulmonary disease.