For example, STRAP overexpression alleviates the TGF-β-induced inhibition of cell growth and induces the tumorigenicity of lung adenocarcinoma (A549) and colon adenocarcinoma (FET) cells [8], indicating an important role of STRAP in tumor development through negative regulation of TGF-β-mediated growth suppression. This evidence concerns the gene TGFB1 and lung adenocarcinoma.