STRAP and colorectal carcinoma: Consistent with this observation, the knockdown of STRAP in murine colon carcinoma cell lines inhibited tumorigenesis, invasion, and metastasis, demonstrating that STRAP increases the invasion and metastasis of CRC partly via the inhibition of the ubiquitin-dependent degradation of β-catenin and the enhancement of Wnt/β-catenin signaling [47].