The correlation between MH and EHS is also supported by evidence collected in animal models: (a) in porcine stress syndrome (PSS), swine carrying a point mutation in RYR1 trigger MH episodes in response to halothane administration but also following exposure to either heat or emotional/physical stress [14, 15]; (b) knock-in mice carrying gain-of-function point mutations in RYR1 linked to MH in humans exhibit heat- and anesthetic-induced MH episodes [16, 17]. This evidence concerns the gene RYR1 and peeling skin syndrome.