TNF and obesity due to melanocortin 4 receptor deficiency: Hand in hand with our data, Pardina et al. showed that the expression of TNF-α did not vary with weight loss in the adipose tissue and liver despite the improvement in body weight and in most of the parameters associated with obesity comorbidities (insulin resistance and dyslipidemia), underlining that TNF-α does not reflect the improvement of inflammation during the first year after bariatric surgery [4].