Our data showed that plasma mSEPT9 had a sensitivity of 61.22% (95% CI: 51.33%–70.27%) for CRC detection using 2/3 algorithm (Table 3), which is higher than other common blood-based biomarker, such as CEA (ranging from 40.9% to 51.8%) [6, 31, 32] and carbohydrate antigen 19-9 (CA19-9) (ranging from 36.4% to 47.8%) [33, 34]. Here, CEACAM5 is linked to colorectal carcinoma.