In silico analysis confirmed that the expression of CXCR4 in the primary tumor significantly correlated not only with the expression of its ligand CXCL12 (Spearman's coefficient, rs = 0.4920) but also with the expression of VIM (rs = 0.4779) and CD163 (rs = 0.4853) (Figure 4(a)). Here, CXCR4 is linked to neoplasm.