CXCR4 and neoplasm: However, only eight genes (CALD1, CD163, COL1A2, CXCR4, ITGAV, SNAI2, TGFB2, and TWIST1), whose expression was upregulated in SLNs of patients who experienced tumor relapse, remained significant after adjustment for multiple testing (Table 1), indicating that both EMT and immune response have a crucial role in the spread of luminal B BC cells to SLNs.