Significant association between EDN1 rs5370 and stroke was revealed under dominant (Pc = 0.012; ORc = 1.657, 95% CI = 1.115–2.462), recessive (Pc = 0.007; ORc = 2.839, 95% CI = 1.331–6.057), and additive (Pc = 0.003; ORc = 3.291, 95% CI = 1.512–7.165—for TT genotype) models of inheritance. This evidence concerns the gene EDN1 and Stroke.