EDN1 and pulmonary arterial hypertension: In recent years, a wide range of case-control studies to test the association between various single nucleotide polymorphisms (SNPs) of the ET-1 (EDN1) and its receptor (EDNRA and EDNRB) genes and development of arterial hypertension (AH) [5, 6], pulmonary hypertension [7], myocardial infarction [8], diabetic retinopathy [9] and nephropathy [10], metabolic syndrome [11], and hemorrhagic stroke [12] have been carried out.