Another possible mechanisms could be attributed to the antioxidative effect (such as inducing the increased activities of SOD and catalase in the serum of RA, alleviating oxidative stress and inflammation, and improving antioxidant and energy metabolic status) [33, 34, 47] and triggered release of endorphins [25] and regulation of immune function as IgG, IgA, and IgM decreased, while IgE did not change evidently after acupuncture in 12 RA patients [23, 32, 64–66]. This evidence concerns the gene CAT and rheumatoid arthritis.