NFKB1 and neoplasm: Volman et al. [75] confirmed that there is modulation of the immune response of enterocytes, where extracts from mushrooms lower the transactivation of NF-kB in Caco-2 cells, with A. blazei Murill and Coprinus comatus having the pronounced decrease in NF-kB transactivation, which can cause tumor cells to stop proliferating, die, or become sensitive to the action of antitumor agents.