For instance, water extracts of Agaricus blazei Murill (AbM) fruiting bodies induce production of TNF-alpha, IL-8, and NO− [25]; it is low molecular weight polysaccharides that suppress tumor growth and angiogenesis in vivo [26], and they contain agaritine and ergosterol which are capable of inducing apoptosis in leukemia cells and inhibit tumor-induced angiogenesis [27, 28]. Ganoderma lucidum polysaccharides and triterpenoids are potent inhibitors of tumor growth in vitro and in vivo [14]. The gene discussed is TNF; the disease is neoplasm.