Based on Mogensen Stage, DN can be divided into five stages: stage I, high perfusion or kidney hypertrophy; stage II, normal urinary albumin excretion rate (UAER); stage III, also called early DN, microalbumin appearing in the urine; stage IV, also called clinical or dominant DN, plenty of albumin appearing in the urine; and stage V, end-stage renal disease (ESRD) [5, 6]. This evidence concerns the gene ALB and stage 5 chronic kidney disease.