AKT1 and leukemia: Simioni et al. [49] used flow cytometry, MTT, to detect MK-2206 (AKT inhibitor) on T cell acute lymphoblastic leukemia (T-ALL) cell lines; the results showed that MK-2206 can block the G0/G1 phase of leukemia cells, inducing apoptosis, thereby reducing the activity of T-ALL cell lines.