In an obesity and hyperglycemia animal model, thiazolidinedione derived partial PPARγ agonist GQ-16 increased UCP-1 protein expression in interscapular brown adipose tissue (BAT) and in epididymal and inguinal white adipose tissue (WAT) to induce WAT browning and treat obesity [45]. This evidence concerns the gene PPARG and Hyperglycemia.