To study the application of “phlebitis ointment decoction” to intervene in the process of acute thrombotic phlebitis, we took the oral Chinese medicine preparation “phlebitis ointment” as the breakthrough point with our intention to investigate the pathological changes of blood vessels, inflammatory factors control (TNF- alpha, IL-6, CRP, and IL-1 beta), and changes of cell biological activity of signal transduction protein kinase PKC and NF-КBp65 [7, 8]. The gene discussed is TNF; the disease is phlebitis.