A total of 437 individuals were excluded: 194 patients had CD4-positive lymphocyte counts lower than 200 cells/μL, 52 patients were not receiving c-ART, 29 patients were younger than 13 years of age, 25 patients did not have complete records, 16 patients received c-ART in other centers, 23 patients had active tuberculosis, and 98 patients had positive TSTs at baseline. The gene discussed is CD4; the disease is tuberculosis.