Defects in the transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), inducible costimulator (ICOS), B-cell-activating factor receptor (BAFF-R), and nuclear factor kappa B subunit 2 (NFKB2) genes have been identified in some patients with CVID [1, 6, 7]. This evidence concerns the gene TNFRSF13B and common variable immunodeficiency.