Following genes were studied: S100A8, FCGR2A, FCGR2B, IL10, MMP8, MMP3, MMP13, VDR, TLR4, MMP2, MPO, ELANE, IL1A, IL1B, IL1RN, CD28, MMP9, DDX39B, NFKBIL1, LTA, TNF, SOD2, IL6, TLR4, TIMP1, and SYN1. In the present study, association tendencies between the studied SNPs in DDX39B (rs7766569, adjusted OR 3.39, 95% CI 1.10–10.43) and MPO (rs2243818, adjusted OR 2.33, 95% CI 0.97–5.58) and dental caries were found; however, statistical significance disappeared after correction for multiple testing (Tables 2 and 3). This evidence concerns the gene TLR4 and dental caries.