MSH2 and Lynch syndrome: MCM9 recruitment and loading into chromatin are MSH2-dependent and strengthens the recruitment of MLH1 to chromatin binding sites, and cells lacking the MMR protein lose the maintenance of genome stability [57] Liu et al. reported that MCM9 unknown significance variants were only observed in a small proportion of Lynch-like syndrome patients and that MCM9 mutations are unable to explain the MSI in most Lynch-like syndrome cases [58].