In our AIP mutation-positive patient cohort, we have eleven cases with extrapituitary neoplasms: two females with breast cancer, three cases with gastrointestinal stromal tumour (two in the same family), two related cases with meningioma [61], one with non-Hodgkin's lymphoma, one male with osteosarcoma and a colon neuroendocrine tumour [8], one with glioma (loss of heterozygosity of the AIP mutant locus was not present [62]), and a 21-year-old female carrier with a lipoma (unpublished). The gene discussed is AIP; the disease is breast cancer.