ICAM1 and gestational diabetes: This is the case of miR-221 and miR-222, whose expression was found to be upregulated in human fetoplacental endothelial cells (fpEC) isolated from third-trimester human placentas after pregnancies complicated by GDM versus healthy pregnancies; importantly, miR-221 and miR-222 were found to target ICAM1 protein species (ICAM-1, V-CAM, and E-selectin), whose expression was reduced in GDM placentas.