Further genotype and clinical features analysis showed that subjects with TT genotype of rs649446 or subjects with AA genotype of rs7109266 in UCP2 had higher HOMA-IR and HOMA-β, subjects with AA genotype of rs7109266 also had higher waist-to-hip ratio, which suggested that subjects with TT genotype of rs649446 or subjects with AA genotype of rs7109266 were more susceptible to develop insulin resistance. Here, UCP2 is linked to Insulin resistance.