Ang II, when it interacts with the carboxypeptidase B (Carb-B) or the ACE-2, produces Ang 1-7 (Ang 1-7) with the capacity to be antiarrhythmic, a vasodilator of the coronary arteries incrementing the concentration of NO, an antifibrotic to attenuate hypertension, among other functions, through the stimulation of the AT2R receptor, the MAS, and the Ang type 7 receptor (AT7R). Here, ANGPT1 is linked to hypertensive disorder.