Next, we tested whether a neutralizing mouse anti-mouse IL-21 monoclonal antibody (mAb) could neutralize anti-CD3 or anti-CD3/IL-21-induced production of proinflammatory cytokines and chemokines from mesLN CD4+ T cells isolated from mice with colitis (Figures 7(a)–7(g)). Here, IL21 is linked to colitis.